History and Research Interests
The objectives of the group are to exploit emerging proteomic technologies to gain insights into cellular signaling networks important in understanding and treatment of disease. Secondly, we are interested in the development of bioinformatics tools to gain insights from the tremendous amount of data generated in modern protemics experiments.
Dr. Salomon did undergraduate studies at Case Western Reserve University, graduate studies at Stanford University with Prof. Chaitan Khosla, and postdoctoral studies at the Genomics Institute of the Novartis Research Foundation with Prof. Peter Schultz. He joined the faculty of Brown University in 2004 where he is Associate Professor of Molecular Biology, Cell Biology, and Biochemistry (MCB).
Facilities, Resources, and Environment
The Salomon Research Group is based in the Laboratories for Molecular Medicine in the Jewelry disctrict of Providence, RI within 1700 square feet of space. The laboratory has 2 LTQ-FTICR from Thermofinnigan and access to a QSTAR XL in the Brown proteomics core facility. Also, the lab has access to an Orbitrap Velos ETD which is located in the NSF/EPSCoR proteomic core facility in the same building. Extensive computational resources include a dedicated 20 terrabyte, RAID-5 data server with automated off-site backup, dedicated 50 core Sequest and a 4 core Mascot clusters, a custom-made High-Throughput Autonomous Proteomic Platform (HTAPP), and a custom-made relational database called PeptideDepot for the validation and visualization of large quantitative proteomic data sets. The lab also has a dedicated tissue culture facility. Within the same research building as the Salomon lab are significant resources including an NMR, FACS, X-ray crystallography, imaging, and transgenic animal facilities.